Second neoplasms after megavoltage radiation for pediatric tumors
نویسندگان
چکیده
منابع مشابه
Genetically mediated Nf1 loss in mice promotes diverse radiation-induced tumors modeling second malignant neoplasms.
Second malignant neoplasms (SMN) are therapy-induced malignancies and a growing problem in cancer survivors, particularly survivors of childhood cancers. The lack of experimental models of SMNs has limited understanding of their pathogenesis. It is currently not possible to predict or prevent this devastating late complication. Individuals with neurofibromatosis I (NF1) are at increased risk of...
متن کاملAntibody-based targeted radiation to pediatric tumors.
Radioimmunotherapy (RIT) for pediatric tumors remains in its infancy despite its potential as an attractive therapeutic modality. Most childhood tumors are radiation sensitive, but the side effects of external beam radiation are well recognized. Despite achieving complete remissions with sophisticated combination therapies, treatment failure primarily results from the inability to eradicate min...
متن کاملMolecular and Cellular Pathobiology Genetically Mediated Nf1 Loss in Mice Promotes Diverse Radiation-Induced Tumors Modeling Second Malignant Neoplasms
Second malignant neoplasms (SMN) are therapy-induced malignancies and a growing problem in cancer survivors, particularly survivors of childhood cancers. The lack of experimental models of SMNs has limited understanding of their pathogenesis. It is currently not possible to predict or prevent this devastating late complication. Individuals with neurofibromatosis I (NF1) are at increased risk of...
متن کاملSecond malignant neoplasms after treatment of childhood acute lymphoblastic leukemia.
PURPOSE Second malignant neoplasms (SMNs) after diagnosis of childhood acute lymphoblastic leukemia (ALL) are rare events. PATIENTS AND METHODS We analyzed data on risk factors and outcomes of 642 children with SMNs occurring after treatment for ALL from 18 collaborative study groups between 1980 and 2007. RESULTS Acute myeloid leukemia (AML; n = 186), myelodysplastic syndrome (MDS; n = 69)...
متن کاملThe evaluation of change in attenuation coefficient of cerrobend block used for radiation protection of healthy tissues in megavoltage photon radiation therapy after multiple melting
Introduction: Protecting the vital organs in radiation therapy is one of the most important issues. Cerrobend alloy, the most common material used as the shield, is melted several times and used for different patients. In this study changes in attenuation coefficient of cerrobend due to melting was investigated. Materials and Methods: In melting furnace, ...
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ژورنال
عنوان ژورنال: Cancer
سال: 2003
ISSN: 0008-543X,1097-0142
DOI: 10.1002/cncr.11356